The US is set to spend $113m on digital economy, energy and infrastructure in Asia which is perceived by many as a move to counter China's growing influence in the region.
US Secretary of State Mike Pompeo made the pledge while outlining the "Indo-Pacific" economic strategy in a speech to business leaders in Washington this week.
Pompeo stated that the US believed in "strategic partnerships not strategic dependency".
The announcement comes at a time when the US and China are butting heads in a tit-for-tat trade war.
Furthermore, the Trump administration strategy to build influence with a regional grouping identified as the "Indo-Pacific", which includes the US West Coast, Southeast Asian nations and India, is seen as a response to China's Belt and Road initiative.
But the funds will be seen as a drop in the ocean compared to the billions Beijing has poured into the rebuilding of ports, roads and railways across Asia and beyond.
The Belt and Road initiative is widely seen as China's attempt to increase its political and strategic influence globally.
Meanwhile, Pompeo made a specific reference to this in his speech to the US Chamber of Commerce. "The United States of America does not invest for political influence, but rather practices partnership economics," he said.
"These funds represent just a down payment on a new era in US economic commitment to peace and prosperity in the Indo-Pacific region."
Despite the amounts involved, analysts say it is a sign that the US intends to increase its engagement with Asian economies.
The US has carried out an increasingly protectionist economic agenda since US President Donald Trump took office in 2016, setting the tone early on when he pulled out of the Trans Pacific Partnership deal last year.
It also slapped tariffs on $34bn of Chinese goods earlier this month and has accused China of intellectual copyright theft.
